Rectal anzesthetics and analgesics



Patented Dec. 26, 1933 RECTAL ANZESTHETICS AND 'ANALGESICS Ferdinand W. Nitardy, Brooklyn, N. Y., assignor to E. R. Squibb & Sons, New York, N. Y., a corporation of New York No Drawing. Application March 31, 1933 Serial No. 663,852

4 Claims. (01. 167-523 This invention relates to rectal anaesthetics and analgesics having an ether-oil base.

As hitherto constituted,combinations of ether with oilsthough Valuable for inducing anaes- 5 thesia or analgesia by rectal instillation, in connection with var ious operations, particularly the management of pregnancy and laborhave been defective in that their presence in the colon has causedirritation and discomfort to the patient, in some cases to such a degree 'asto result in expulsion of the mixture by reflex action; in consequence of which failure to retain, there has been serious interference with the induction of adequate anaesthesia or analgesia. I

It is the object of this invention to provide ether-oil rectal anasthetics and analgesics that give rise to the and discomfort, tained and thus anaesthetic and minimum of colonic irritation and are therefore completely recapable of exercising their full analgesic efiect.

In the practice of this invention, ether-oil combinations are mixed with a small proportion of an interface-tension depressant. By this addition, the discomfort the patient would other wise experience is largely prevented, and'hence theefiiciency with which anaesthesia or analgesia may be induced is markedly increased.

Among the interface-tension depressants that may be used are sulfonated olein, and alkalimetal and ammonium salts thereof; sulfonated oleic acid, and alkali-metal and ammonium derivatives thereof; mono-esters of triethanolaminc; and sulfonated castor, corn, cottonseed, olive, almond, peanut, peach-kernel, and neatsfoot oils. any oleaginous The oil in the ether-oil basev may be material, especially mineral,

vegetable, and animal oils, fats, and greasese. g., liquid petrolatum, olive oil, lanolin'and is preferably used in the proportion of between one-half and three times the volume of ether.

As an examp tuted in accord comprise As a further example, a rectal analgesic constituted in accordance with this invention and especially. suitable for obstetrical purposes may have the formula Ether -s Quinine 20 gn. Alcohol 45 min. Liquid petrolatum enough to make 4 fl. oz. Sulfonated olein 0.1% by weight It will be understood that the foregoing examples are merelyillustrative and by no means limitative of the invention, which may be 'variously otherwise embodied-for instance, as to the specific interface-tension depressants and oils and other ingredients employed, and as to their relative proportions-within' the scope of the appended claims.

I claim:

1. A rectal anaesthetic or analgesic comprising ether, an oil, and an interface-tension depressantr 2. A rectal anaesthetic or analgesic comprising (1) ether, (2). an oil, and (3) a substance selected from the group consisting of sulfonated 'olein and alkali-metal and ammonium salts 3. A rectal anaesthetic or analgesic comprising ether, an oil, and sulfonated olein.

" 4. A rectal anaesthetic or analgesic comprising ether, an oil, and sulfonated olive oil.

FERDINAND w. NITARDY. 

